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Electrospun scaffolds with antimicrobial and wound-healing capabilities utilizing bacteriophages, mesenchymal stem cell–derived factors and MXenes – AntiMicroMXen
Call Topic: Advanced materials and technologies for health applications
The AntiMicroMXen project is funded under M-era.net program t is a collaboration between several esteemed partners:
Hirszfeld Institute of Immunology and Experimental Therapy (HI), Polish Academy of Sciences – Wroclaw, Poland
University of Latvia (UL) – Riga, Latvia
NANOCARBON TECH Sp. z o.o. (NCT) – Poznań, Poland
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. – Munich, Germany
Fraunhofer Institute of Ceramic Technologies and Systems (IKTS) – Dresden, Germany (AntiMicroMXen Project coordinator: Dr. Natalia Beshchasna)
The project represents a significant step forward in wound healing technology, addressing critical challenges faced by healthcare providers and patients alike. NANOCARBON TECH is excited to be part of this groundbreaking initiative, delivering meaningful results that can improve the quality of life for millions of people worldwide.
Project summary:
NANOCARBON TECH is proud to be part of the innovative AntiMicroMXen research project, which aims to revolutionize wound healing therapies. Chronic wounds affect around 4 million Europeans annually, with approximately 1% of individuals in highly developed countries experiencing this issue. Traditional therapies are costly, consuming about 2-4% of European healthcare spending, and despite some success, up to 10% of cases lead to severe complications. This figure rises to 30% among patients with diabetes or weakened immune systems. Furthermore, approximately 10-20% of infected wounds are contaminated with methicillin-resistant Staphylococcus aureus (MRSA), which significantly complicates treatment.
The AntiMicroMXen project is focused on developing a new generation of advanced wound dressings made from electrospun polycaprolactone (PCL), polylactic acid (PLA), and gelatin, incorporating bacteriophages targeting S. aureus, as well as MXenes with antibacterial and hemostatic properties. These dressings will also include regenerative factors derived from immortalized human adipose-derived mesenchymal stem cells (HATMSC). The secretome produced by HATMSC has been shown to exhibit strong pro-proliferative and pro-angiogenic activities, accelerating tissue regeneration.
At NANOCARBON TECH, we are contributing to the development of MXene-based materials that provide excellent antimicrobial properties, playing a critical role in enhancing the effectiveness of these innovative wound dressings. Additionally, we are helping to ensure that these materials are compatible with advanced regenerative therapies, bringing us closer to a more efficient, comprehensive solution for chronic wound care.
The project represents a significant step forward in wound healing technology, addressing critical challenges faced by healthcare providers and patients alike. NANOCARBON TECH is excited to be part of this groundbreaking initiative, delivering meaningful results that can improve the quality of life for millions of people worldwide.
Project Details:
Project Number M-ERA.NET3/2023/16/AntiMicroMXen/2025, budget of NANOCARBONTECH 1121880 zl, funded by NCBR
Call 2023
Call Topic
Advanced materials and technologies for health applications
Project start
01.06.2024
Project end
01.06.2027
Total project costs
1.359.040 €
Total project funding
1.299.040 €
TRL
2 – 4
Coordinator
Dr. Natalia Beshchasna
natalia.beshchasna@ikts.fraunhofer.de
Fraunhofer Institute for Ceramic Technologies and Systems IKTS, Maria-Reiche Straße 2, 01109 Dresden, Germany